Article

Fibroblast-encoded inflammatory memory orchestrates recurrent skin inflammation <i>via</i> NNMT-dependent metabolic remodeling

2026-04-30

Abstract excerpt

Chronic skin inflammation frequently recurs at the same anatomical sites after therapy withdrawal, implying stromal cells may encode local inflammatory memory. Here, we identified nicotinamide N-methyltransferase (NNMT) as a central metabolic-epigenetic regulator of fibroblast inflammatory memory enabling psoriasis relapse. Single-cell and spatial transcriptomics revealed that dermal fibroblasts acquire a persiste...

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Literature Corpus work: 1fe0c756-0c75-5ca7-9cc6-baf658abcbaf
DOI: 10.64898/2026.04.27.721223

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