Article

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

2019-10-04

Abstract excerpt

The human pregnane X receptor (PXR), a master regulator of drug metabolism, has important roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off-target toxicity. Based on prior work that established microbial (indole) metabolites as PXR ligands, we proposed microbial metabolite mimicry as a novel strategy for drug discovery that allows to exploit previously unexplore...

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Literature Corpus work: 5dfe0bfd-188f-5ec8-a2cb-0afe851c086d
DOI: 10.1101/792671

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