Article
Microbially guided discovery and biosynthesis of biologically active natural products
2021-03-18
Abstract excerpt
<title>Abstract</title> <p>The design of small molecules that inhibit disease-relevant proteins represents a longstanding challenge of medicinal chemistry. Here, we describe an approach for encoding this challenge—the inhibition of a human drug target—into a microbial host and using it to guide the discovery and biosynthesis of targeted, biologically active natural products. This approach identified two previousl...
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Identifiers and source
- Literature Corpus work
- 788a382d-5edf-5efc-9c9a-2c5757ad4ef1
- DOI
- 10.21203/rs.3.rs-92116/v2