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Mechanisms and Therapeutic Advances of PXR in Metabolic Diseases and Cancer

20 Aug 2025

Abstract excerpt

The pregnane X receptor (PXR), a ligand-activated nuclear receptor, plays a central role in regulating the metabolism of both endogenous substances and xenobiotics. In recent years, increasing evidence has highlighted its involvement in chronic diseases, particularly metabolic disorders and cancer. PXR modulates drug-metabolizing enzymes, transporters, inflammatory factors, lipid metabolism, and immune-related...

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PMID: 40869350
DOI: 10.3390/ijms26168029

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