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Article

Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism.

Cell reports - 11 Oct 2022

Magnotti Flora, Chirita Daria, Dalmon Sarah, Martin Amandine, Bronnec Pauline, Sousa Jeremy, Helynck Olivier, Lee Wonyong, Kastner Daniel L, Chae Jae Jin, McDermott Michael F, Belot Alexandre, Popoff Michel, Sève Pascal, Georgin-Lavialle Sophie, Munier-Lehmann Hélène, Tran Tu Anh, De Langhe Ellen, Wouters Carine, Jamilloux Yvan, Henry Thomas

Abstract excerpt

The pyrin inflammasome acts as a guard of RhoA GTPases and is central to immune defenses against RhoA-manipulating pathogens. Pyrin activation proceeds in two steps. Yet, the second step is still poorly understood. Using cells constitutively activated for the pyrin step 1, a chemical screen identifies etiocholanolone and pregnanolone, two catabolites of testosterone and progesterone, acting at low concentrations...

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Identifiers

PMID: 36223753
DOI: 10.1016/j.celrep.2022.111472
PMCID: PMC9626387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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