Article
Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators.
Structure (London, England : 1993) - 8 Jan 2026
Huber Andrew D, Garcia-Maldonado Efren, Lin Wenwei, Poudel Shyaron, Wu Jing, Miller Darcie J, Chen Taosheng
Abstract excerpt
Nuclear receptor antagonists are used to treat various diseases, but the precise antagonist mechanisms differ among receptors and compounds. Understanding the interplay between ligand-receptor interactions and transcriptional outcomes is critical. The nuclear receptor pregnane X receptor (PXR) is activated by many medicinal compounds and upregulates drug metabolism genes in response, decreasing efficacy and/or...
Read the complete abstract on PubMedTopics
- Pregnane X Receptor
- Humans
- Ligands
- Protein Binding
- Binding Sites
- Transcription, Genetic