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Article

Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design

2019-05-17

Abstract excerpt

<h4>ABSTRACT</h4> As a key regulator of metabolism and inflammation, the orphan nuclear hormone receptor, Liver Receptor Homolog-1 (LRH-1), has potential as a therapeutic target for diabetes, nonalcoholic fatty liver disease, and inflammatory bowel diseases. Discovery of LRH-1 modulators has been difficult, in part due to the tendency for synthetic compounds to bind unpredictably within the lipophilic binding poc...

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Literature Corpus work
e5742c10-2f46-5e8c-a124-b8179ec8614d
DOI
10.1101/639732
Open publication

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