Article

Chemoproteomics of microbiota metabolites reveals small-molecule agonists for orphan receptor GPRC5A

2021-12-16

Abstract excerpt

<h4>ABSTRACT</h4> The microbiota generates diverse metabolites that can engage multiple pathways to modulate host physiology and disease, but their protein targets and mechanism(s) of action have not been fully elucidated. To address this challenge, we focused on indole-3-acetic acid (IAA), a prominent microbiota metabolite, and developed IAA-based chemical reporters for proteomic studies. We discovered that IAA...

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Literature Corpus work: e3cdcfd5-3cf4-55ec-a9f5-baa3831ce8ad
DOI: 10.1101/2021.12.16.472979

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