Article

Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

2021-10-29

Abstract excerpt

The pyrin inflammasome acts as a guard of RhoA GTPases and is central to immune defences against RhoA-manipulating pathogens. Pyrin activation proceeds in two steps. Yet, the second step is still poorly understood. Using cells constitutively activated for the pyrin step 1, a chemical screen identified etiocholanolone and pregnanolone, two catabolites of testosterone and progesterone, acting at low concentrations a...

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Literature Corpus work: ab4bc1cf-0069-5998-926c-15e8cd1db28f
DOI: 10.1101/2021.10.29.466454

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