Article

RUNX1-ETO and CBFβ-MYH11 converge on aberrant activation of BCAT1 to confer a therapeutic vulnerability in core binding factor-acute myeloid leukemia

2023-07-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Effective targeted therapy is an unmet clinical need for core binding factor-acute myeloid leukemia (CBF-AML) characterized by RUNX1-ETO and CBFb-MYH11 fusions. However, therapeutically targeting oncogenic fusions involving transcription factors remains challenging. Recent studies point to aberrant amino acid metabolisms as actionable therapeutic targets. <bold>...

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Literature Corpus work: 5df96383-115e-561d-b29a-51f82ce9a3d9
DOI: 10.21203/rs.3.rs-3124393/v1

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