Article

LncRNA BCYRN1 regulates mitochondrial MT-ND1/4/5 transcription via heavy strand promoter methylation to promote oxidative phosphorylation and proliferation in acute myeloid leukemia

2026-07-07

Abstract excerpt

<title>Abstract</title> <p>Background Acute myeloid leukemia (AML) is the most common adult acute leukemia. Treatment resistance and relapse remain the major clinical challenges. AML cells exhibit a unique dependence on mitochondrial oxidative phosphorylation (OXPHOS), which provides a promising metabolic vulnerability for targeted therapy. Methods Bioinformatic analysis was performed using integrated TCGA-LAML...

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Literature Corpus work: 284a2a03-b445-5145-b2bd-7e4d4689dcf8
DOI: 10.21203/rs.3.rs-10158593/v1

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