The clinical mutatome of core binding factor leukemia.

doi:10.1038/s41375-019-0697-0

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Article

The clinical mutatome of core binding factor leukemia.

Leukemia - 1 Jun 2020

Opatz Sabrina, Bamopoulos Stefanos A, Metzeler Klaus H, Herold Tobias, Ksienzyk Bianka, Bräundl Kathrin, Tschuri Sebastian, Vosberg Sebastian, Konstandin Nikola P, Wang Christine, Hartmann Luise, Graf Alexander, Krebs Stefan, Blum Helmut, Schneider Stephanie, Thiede Christian, Middeke Jan Moritz, Stölzel Friedrich, Röllig Christoph, Schetelig Johannes, Ehninger Gerhard, Krämer Alwin, Braess Jan, Görlich Dennis, Sauerland Maria Cristina, Berdel Wolfgang E, Wörmann Bernhard J, Hiddemann Wolfgang, Spiekermann Karsten, Bohlander Stefan K, Greif Philipp A

Abstract excerpt

The fusion genes CBFB/MYH11 and RUNX1/RUNX1T1 block differentiation through disruption of the core binding factor (CBF) complex and are found in 10-15% of adult de novo acute myeloid leukemia (AML) cases. This AML subtype is associated with a favorable prognosis; however, nearly half of CBF-rearranged patients cannot be cured with chemotherapy. This divergent outcome might be due to additional mutations, whose...

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Identifiers

PMID: 31896782
DOI: 10.1038/s41375-019-0697-0
PMCID: PMC7266744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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