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Article

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

12 Jun 2019

Abstract excerpt

Abstract Epigenetic gene regulation and metabolism are highly intertwined, yet little is known about whether altered epigenetics influence cellular metabolism during cancer progression. Here, we show that EZH2 and NRASG12D mutations cooperatively induce progression of myeloproliferative neoplasms to highly penetrant, transplantable, and lethal myeloid leukemias in mice. EZH1, an EZH2 homolog, is indispensable for...

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Share to Acute Myeloid Leukemia Research
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PMID: 31189531
DOI: 10.1158/2159-8290.cd-19-0152

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