Article

BCLAF1 links RNA splicing to ATF4-dependent metabolic adaptation in acute myeloid leukemia

2026-01-22

Abstract excerpt

Acute myeloid leukemia (AML) is driven by a combination of genetic alterations and non-mutational mechanisms that disrupt normal hematopoiesis and support leukemic cell survival. While the mutational landscape of AML is well characterized, the non-genetic processes that sustain leukemic maintenance remain comparatively less understood. Using human AML cell lines and murine models of AML, we identify BCL2-associate...

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Literature Corpus work: b7544e06-ee88-5438-9586-d8efef1ed75f
DOI: 10.64898/2026.01.19.700325

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