Article

Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback

2025-05-26

Abstract excerpt

Antiviral resistance evolution poses a major obstacle for controlling viral infections. A promising strategy is to target shared viral proteins that allow drug susceptible viruses to sensitize resistant ones during cellular coinfection, muting selection for resistance. Pocapavir, a poliovirus capsid inhibitor, employs this sociovirological strategy. While susceptible viruses significantly suppressed resistance in...

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Literature Corpus work: 5df651a5-01da-5f18-b9a3-83b1709a74c4
DOI: 10.1101/2025.05.20.655113

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