Article

Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistance

2014-12-19

Abstract excerpt

Infections with rapidly evolving pathogens are often treated using combinations of drugs with different mechanisms of action. One of the major goals of combination therapy is to reduce the risk of drug resistance emerging during a patient’s treatment. While this strategy generally has significant benefits over monotherapy, it may also select for multi-drug resistant strains, which present an important clinical and...

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Identifiers and source

Literature Corpus work: 8b633c1a-9448-5f91-bc49-4d0a71222bed
DOI: 10.1101/013003

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