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Article

Conflicting Selection Pressures Will Constrain Viral Escape from Interfering Particles: Principles for Designing Resistance-Proof Antivirals.

PLoS computational biology - 1 May 2016

Rast Luke I, Rouzine Igor M, Rozhnova Ganna, Bishop Lisa, Weinberger Ariel D, Weinberger Leor S

Abstract excerpt

The rapid evolution of RNA-encoded viruses such as HIV presents a major barrier to infectious disease control using conventional pharmaceuticals and vaccines. Previously, it was proposed that defective interfering particles could be developed to indefinitely control the HIV/AIDS pandemic; in individual patients, these engineered molecular parasites were further predicted to be refractory to HIV's mutational...

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Identifiers

PMID: 27152856
DOI: 10.1371/journal.pcbi.1004799
PMCID: PMC4859541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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