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Article

Coevolutionary dynamics of viruses and their defective interfering particles.

PLoS computational biology - 1 May 2026

Muthupandiyan Shiv, Yin John

Abstract excerpt

Defective interfering particles (DIPs) are viral mutants that arise naturally during infection. Because they lack one or more essential functions, DIPs cannot replicate on their own, but they can parasitize intact viruses during coinfection by competing for growth resources, thereby interfering with viral replication. The evolutionary interplay between viruses and their DIPs involves growth, mutation,...

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Identifiers

PMID: 42160357
DOI: 10.1371/journal.pcbi.1014300
PMCID: PMC13232958

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