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Article

Autonomous targeting of infectious superspreaders using engineered transmissible therapies.

PLoS computational biology - 1 Mar 2011

Metzger Vincent T, Lloyd-Smith James O, Weinberger Leor S

Abstract excerpt

Infectious disease treatments, both pharmaceutical and vaccine, face three universal challenges: the difficulty of targeting treatments to high-risk 'superspreader' populations who drive the great majority of disease spread, behavioral barriers in the host population (such as poor compliance and risk disinhibition), and the evolution of pathogen resistance. Here, we describe a proposed intervention that would...

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PMID: 21483468
DOI: 10.1371/journal.pcbi.1002015
PMCID: PMC3060167

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