Article

Dosage-sensitivity of human transcription factor genes

2019-01-23

Abstract excerpt

Changes in the copy number of protein-coding genes would lead to detrimental effects if the consequent changes in protein concentration disrupt essential cellular functions. Large-scale genomic studies have identified thousands of dosage-sensitive genes in human genome. We are interested in the dosage-sensitivity of transcription factor (TF) genes whose products are essential for the growth, division and different...

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Literature Corpus work: 5def7ba2-320e-5de2-86b4-e0a9f31aa282
DOI: 10.1101/528554

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