Article

Evolution of dosage-sensitive genes by tissue-restricted expression changes

2024-10-18

Abstract excerpt

Dosage-sensitive genes have characteristic patterns of evolution that include being refractory to small-scale duplication, depleted on human benign copy number variants (CNVs) and enriched on pathogenic CNVs. This intolerance to copy number change is likely due to an expression constraint that exists in one or more tissues. While genomic copy number changes alter the encompassed genes’ expression across all tissue...

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Literature Corpus work: 7e7ac94e-317a-59ab-8559-32342d8a6171
DOI: 10.1101/2024.10.17.618887

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