Article
Gene dosage effects: nonlinearities, genetic interactions, and dosage compensation.
Trends in genetics : TIG - 1 Jul 2013
Veitia Reiner A, Bottani Samuel, Birchler James A
Abstract excerpt
High-throughput genomic analyses have shown that many mutations, including loss-of-function (LOF) mutations, are present in diseased as well as in healthy individuals. Gene dosage effects due to deletions, duplications, and LOF mutations provide avenues to explore oligo- and multigenic inheritance. Here, we focus on several mechanisms that mediate gene dosage effects and analyze biochemical interactions among...
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