Article

Precise modulation of transcription factor levels reveals drivers of dosage sensitivity

2022-06-14

Abstract excerpt

<h4>ABSTRACT</h4> Transcriptional regulation displays extensive robustness, but human genetics indicate sensitivity to transcription factor (TF) dosage. Reconciling such observations requires quantitative studies of TF dosage effects at trait-relevant ranges, which are lacking to date. TFs play central roles in both normal-range and disease-associated variation in facial morphology; we therefore developed an appr...

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Literature Corpus work: d1b5a719-0611-5535-8986-84029673f500
DOI: 10.1101/2022.06.13.495964

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