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Article

Dosage sensitivity shapes the evolution of copy-number varied regions.

PloS one - 10 Mar 2010

Schuster-Böckler Benjamin, Conrad Donald, Bateman Alex

Abstract excerpt

Dosage sensitivity is an important evolutionary force which impacts on gene dispensability and duplicability. The newly available data on human copy-number variation (CNV) allow an analysis of the most recent and ongoing evolution. Provided that heterozygous gene deletions and duplications actually change gene dosage, we expect to observe negative selection against CNVs encompassing dosage sensitive genes. In...

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Identifiers

PMID: 20224824
DOI: 10.1371/journal.pone.0009474
PMCID: PMC2835737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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