Article

Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsies

2020-08-13

Abstract excerpt

<title>Abstract</title> <p>Precision medicine approaches in pancreatic ductal adenocarcinoma (PDAC) are imperative for improving disease outcomes. However, the long-term fidelity of recently deployed ex vivo preclinical platforms, such as patient-derived organoids (PDOs), remains unknown. Through single-cell RNA sequencing (scRNA-seq), we identify substantial transcriptomic evolution of PDOs propagated from the p...

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Literature Corpus work: 1ce0a2ed-296d-57a8-a2c1-40481e29452f
DOI: 10.21203/rs.3.rs-51951/v1

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