Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acidic pH irreversibly activates the signaling enzyme SARM1.

The FEBS journal - 1 Dec 2021

Zhao Yong Juan, He Wei Ming, Zhao Zhi Ying, Li Wan Hua, Wang Qian Wen, Hou Yun Nan, Tan Yongjun, Zhang Dapeng

Abstract excerpt

SARM1, an executioner in axon degeneration, is an autoinhibitory NAD-consuming enzyme, composed of multiple domains. NMN and its analogs, CZ-48 and VMN, are the only known activators, which can release the inhibitory ARM domain from the enzymatic TIR domain. Here, we document that acid can also activate SARM1, even more efficiently than NMN, possibly via the protonation of the negative residues. Systematic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acids
Share to Armadillo Domain Proteins
Share to Biocatalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Enzyme Inhibitors

Share to Niacinamide

Share to Protein Domains

Source

Identifiers

PMID: 34213829
DOI: 10.1111/febs.16104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acidic pH irreversibly activates the signaling enzyme SARM1.PMID 34213829Read ↗

SARM1, the executioner of axon degeneration, is an ADP-ribosyl transferase and autoMARylation negatively regulates its activationSemantic proximity Read ↗

Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo EfficacySemantic proximity Read ↗

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.Semantic proximity Read ↗

Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicitySemantic proximity Read ↗

Multiple domain interfaces mediate SARM1 autoinhibition.Semantic proximity Read ↗

The NAD <sup>+</sup> precursor NMN activates dSarm to trigger axon degeneration in <i>Drosophila</i>Semantic proximity Read ↗

A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate ImmunitySemantic proximity Read ↗

Adaptation of a commercial NAD quantification kit to assay the base exchange activity of SARM1Semantic proximity Read ↗

SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low dosesSemantic proximity Read ↗

Constitutively active <i>SARM1</i> variants found in ALS patients induce neuropathySemantic proximity Read ↗

Enrichment of <i>SARM1</i> alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disordersSemantic proximity Read ↗

A dNmnat-sensitized <i>in vivo</i> platform for unbiased discovery of regulators of neurodegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.