Programmed axon degeneration gene variants in human disease.

doi:10.1016/j.expneurol.2026.115891

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Article

Programmed axon degeneration gene variants in human disease.

Experimental neurology - 1 Oct 2026

Hopkins Eleanor L, Williams Pete A

Abstract excerpt

BACKGROUND: Programmed axon degeneration (PAD; also known as Wallerian degeneration) is a conserved pathway controlling axon breakdown following injury or metabolic stress. PAD is driven by the depletion of nicotinamide adenine dinucleotide (NAD) through loss of the pro-survival enzyme NMNAT2 and activation of the pro-degenerative NADase SARM1. Recent genetic studies have identified pathogenic variants in PAD...

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Identifiers

PMID: 42341897
DOI: 10.1016/j.expneurol.2026.115891

Genes

SARM1
NMNAT2
NAMPT
NMNAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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