Article

Biophysical dissection of SOX18/NR2F2 transcriptional antagonism reveals mechanisms of venous differentiation and drug action in vascular malformation

2025-04-27

Abstract excerpt

Translating genomic discoveries into therapies for rare genetic disorders remains a significant challenge, particularly for variants of unknown significance (VUS) where molecular mechanisms are unclear. This is particularly relevant in vascular malformations, where venous differentiation remains poorly understood, and the role of transcription factors in specifying venous identity is only beginning to be elucidate...

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Literature Corpus work: 5d5c140c-c384-5485-a0f2-ad9608a0cb7a
DOI: 10.1101/2025.04.25.650344

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