Article

E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension

2023-02-16

Abstract excerpt

<h4>Rationale</h4> Rare genetic variants and genetic variation at loci in an enhancer in SRY-Box Transcription Factor 17 (SOX17) are identified in patients with idiopathic pulmonary arterial hypertension (PAH) and PAH with congenital heart disease. However, the exact role of genetic variants or mutation in SOX17 in PAH pathogenesis has not been reported. <h4>Objectives</h4> To investigate the role of SOX17 defic...

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Literature Corpus work: ae5075e7-3fb3-520a-bbcb-e3aa1777b09d
DOI: 10.1101/2023.02.15.528740

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