Article

Identification of drug candidates for rescue of SOX17 gene targets in pulmonary arterial hypertension

2026-05-21

Abstract excerpt

<h4>Background</h4> Both rare and common variants in the SRY-Box Transcription Factor 17 ( SOX17 ) locus are associated with pulmonary arterial hypertension (PAH). SOX17 dysregulation leads to pulmonary artery endothelial cell (PAEC) dysfunction and the obstructive remodelling that characterises PAH. <h4>Hypothesis</h4> Impaired SOX17 expression contributes to the pathogenesis of PAH. Restoring the function o...

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Literature Corpus work: a6e685cb-8073-5a88-a8d7-47bd666a4fd2
DOI: 10.64898/2026.05.14.725284

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