Article

Biochemical and functional investigations into the contribution of SOX17 mutations to the pathogenesis of pulmonary arterial hypertension

2021-01-01

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a rare fatal disease characterised by endothelial dysfunction and obliteration of small pulmonary arteries. The resulting increase in pulmonary arterial pressure and right ventricular afterload ultimately causes death by right heart failure. Current available treatments show little impact on patient mortality and there is thus an urgent need to better understand the causes...

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Literature Corpus work: 3ce0330b-0e86-591b-b37c-aaa3e6246124
DOI: 10.17863/cam.72731

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