Article
Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery.
Cell stem cell - 6 Feb 2025
Pan Zihang, Yao Qiyang, Kong Weijing, Ma Xiaojing, Tian Liangliang, Zhao Yun, Zhu Shuntian, Chen Sheng, Sun Mengze, Liu Jiao, Jiang Simin, Ma Jianxun, Liu Qijia, Peng Xiaohong, Li Xiaoxia, Hong Zixuan, Hong Yi, Wang Xue, Liu Jiarui, Zhang Jingjing, Zhang Wei, Sun Bingbing, Pahlavan Sara, Xia Youchen, Shen Weimin, Liu Yuyong, Jiang Wenjian, Xie Zhengwei, Kong Wei, Wang Xi, Wang Kai
Abstract excerpt
Venous malformations (VMs) represent prevalent vascular anomalies typically attributed to non-inherited somatic mutations within venous endothelial cells (VECs). The lack of robust disease models for VMs impedes drug discovery. Here, we devise a robust protocol for the generation of human induced VECs (iVECs) through manipulation of cell-cycle dynamics via the retinoic signaling pathway. We introduce an L914F...
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