Article
A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity.
Nucleic acids research - 8 Nov 2021
McCann Alex J, Lou Jieqiong, Moustaqil Mehdi, Graus Matthew S, Blum Ailisa, Fontaine Frank, Liu Hui, Luu Winnie, Rudolffi-Soto Paulina, Koopman Peter, Sierecki Emma, Gambin Yann, Meunier Frédéric A, Liu Zhe, Hinde Elizabeth, Francois Mathias
Abstract excerpt
Few genetically dominant mutations involved in human disease have been fully explained at the molecular level. In cases where the mutant gene encodes a transcription factor, the dominant-negative mode of action of the mutant protein is particularly poorly understood. Here, we studied the genome-wide mechanism underlying a dominant-negative form of the SOX18 transcription factor (SOX18RaOp) responsible for both...
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