Article

Loss of PGC1α drives extracellular matrix remodelling in prostate cancer through CTHRC1

2026-05-08

Abstract excerpt

<h4>ABSTRACT</h4> Despite the high curation rate of localized prostate cancer, the fraction of patients that progress to metastasis still accounts for thousands of deaths worldwide, underscoring the need to identify early molecular events that prime tumours for aggressive disease. Here, we demonstrate that loss of the metabolic transcriptional coactivator PGC1α drives early extracellular matrix (ECM) remodelling...

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Literature Corpus work: 5d334620-75d1-5e62-81e6-c63ddf55249e
DOI: 10.64898/2026.05.05.722659

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