Article
Identification of transcription factor co-regulators that drive prostate cancer progression.
Scientific reports - 23 Nov 2020
Siddappa Manjunath, Wani Sajad A, Long Mark D, Leach Damien A, Mathé Ewy A, Bevan Charlotte L, Campbell Moray J
Abstract excerpt
In prostate cancer (PCa), and many other hormone-dependent cancers, there is clear evidence for distorted transcriptional control as disease driver mechanisms. Defining which transcription factor (TF) and coregulators are altered and combine to become oncogenic drivers remains a challenge, in part because of the multitude of TFs and coregulators and the diverse genomic space on which they function. The current...
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