Article

Genome-wide analyses of transcription factors and co-regulators across seven cohorts identified reduced PPARGC1A expression as a driver of prostate cancer progression

2020-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Defining altered transcription factor (TF) and coregulators that are oncogenic drivers remains a challenge, in part because of the multitude of TFs and coregulators. We addressed this challenge by using bootstrap approaches to test how expression, copy number alterations or mutation of TFs (n = 2662), coactivators (COA; n= 766); corepressor (COR; n = 599); mixed function coregulators (MIXED; n =...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ad2dcd24-4c38-5956-b828-bc571176923d
DOI: 10.1101/2020.05.12.091066

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide analyses of transcription factors and co-regulators across seven cohorts identified reduced PPARGC1A expression as a driver of prostate cancer progressionDOI 10.1101/2020.05.12.091066Read

Identification of transcription factor co-regulators that drive prostate cancer progression.Semantic proximity Read

Convergence of dispersed regulatory mutations predicts driver genes in prostate cancerSemantic proximity Read

A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancerSemantic proximity Read

Uncovering somatic genetic drivers in prostate cancer through comprehensive genome-wide analysis.Semantic proximity Read

Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrenceSemantic proximity Read

EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cellsSemantic proximity Read

Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network.Semantic proximity Read

Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanismsSemantic proximity Read

The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivoSemantic proximity Read

TOP2A and PPARGC1A differentiate chromatin regulator-related subtypes for prostate cancer patients undergoing radical prostatectomySemantic proximity Read

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer.Semantic proximity Read

RNA modification Regulators' Co-Expression Score (RMRCoeS) predicts biochemical recurrence and therapy response in prostate cancer: A multi-omics and experimental validation study.Semantic proximity Read