Article

Intrinsic errors in mitochondrial translation trigger a decline in cell fitness

2025-10-15

Abstract excerpt

Defects in the faithful expression of the human mitochondrial genome underlies disease states, from rare inherited disorders to common pathologies and the aging process itself. The ensuing decrease in the capacity for oxidative phosphorylation alone cannot account for the phenotype complexity associated with disease. Here, we address how aberrations in mitochondrial nascent chain synthesis per se exert a decline...

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Literature Corpus work: 5d26da99-65c3-5c61-91ec-fe2042e5d1e1
DOI: 10.1101/2025.10.13.682189

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