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Mitochondrial Drivers of Aging: An Integrative Bioenergetic and Genomic Framework for Healthspan Regulation

2026-02-02

Abstract excerpt

Mitochondrial dysfunction is increasingly recognized as a central, integrative driver of biological aging and a convergent mechanism underlying multiple age-associated pathologies. This review synthesizes current evidence identifying a coordinated network of mitochondrial “drivers of aging” that collectively erode cellular homeostasis and organismal resilience. Core processes include decline in ATP production, imp...

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Literature Corpus work
090ff2cf-10df-5bd1-b631-85a767d54939
DOI
10.20944/preprints202602.0026.v1
Open publication

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