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Article

Proteotoxic stress promotes entrapment of ribosomes and misfolded proteins in a shared cytosolic compartment.

Nucleic acids research - 17 Apr 2020

Ghosh Arnab, Williams Loren Dean, Pestov Dimitri G, Shcherbik Natalia

Abstract excerpt

Cells continuously monitor protein synthesis to prevent accumulation of aberrant polypeptides. Insufficient capacity of cellular degradative systems, chaperone shortage or high levels of mistranslation by ribosomes can result in proteotoxic stress and endanger proteostasis. One of the least explored reasons for mistranslation is the incorrect functioning of the ribosome itself. To understand how cells deal with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32030400
DOI: 10.1093/nar/gkaa068
PMCID: PMC7144922

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