Article

Human gene regulatory evolution is driven by the divergence of regulatory element function in both <i>cis</i> and <i>trans</i>

2023-02-15

Abstract excerpt

<h4>SUMMARY</h4> Gene regulatory divergence between species can result from cis -acting local changes to regulatory element DNA sequences or global trans -acting changes to the regulatory environment. Understanding how these mechanisms drive regulatory evolution has been limited by challenges in identifying trans -acting changes. We present a comprehensive approach to directly identify cis- and trans- diverg...

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Literature Corpus work: 79dbfaf5-be49-59d0-80c4-a080ee528eeb
DOI: 10.1101/2023.02.14.528376

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