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From Plankton to Primates: How VSP Sequence Diversity Shapes Voltage Sensing

2025-09-26

Abstract excerpt

Voltage-sensing phosphatases (VSPs) provide a conserved framework for dissecting the mechanics of voltage sensing and for engineering genetically encoded voltage indicators (GEVIs). To evaluate how natural sequence diversity shapes function, we compared VSP voltage-sensing domains (VSDs) from multiple species. Every construct that reached the plasma membrane produced a voltage-dependent optical signal, underscorin...

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Literature Corpus work
5d1c1d74-0d69-5412-b12b-31074acdd623
DOI
10.20944/preprints202509.2263.v1
Open publication

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From Plankton to Primates: How VSP Sequence Diversity Shapes Voltage SensingDOI 10.20944/preprints202509.2263.v1
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