Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Directed Evolution of Key Residues in Fluorescent Protein Inverses the Polarity of Voltage Sensitivity in the Genetically Encoded Indicator ArcLight.

ACS chemical neuroscience - 15 Mar 2017

Platisa Jelena, Vasan Ganesh, Yang Amy, Pieribone Vincent A

Abstract excerpt

Genetically encoded calcium indicators (GECIs) produce unprecedentedly large signals that have enabled routine optical recording of single neuron activity in vivo in rodent brain. Genetically encoded voltage indicators (GEVIs) offer a more direct measure of neuronal electrical status, however the signal-to-noise characteristics and signal polarity of the probes developed to date have precluded routine use in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebral Cortex
Share to Electric Stimulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Green Fluorescent Proteins

Share to HEK293 Cells

Share to Luminescent Proteins

Share to Molecular Biology

Share to Patch-Clamp Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 28045247
DOI: 10.1021/acschemneuro.6b00234
PMCID: PMC5355904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Directed Evolution of Key Residues in Fluorescent Protein Inverses the Polarity of Voltage Sensitivity in the Genetically Encoded Indicator ArcLight.PMID 28045247Read ↗

Excitation wavelength optimization improves photostability of ASAP-family GEVIs.Semantic proximity Read ↗

Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator.Semantic proximity Read ↗

Enhanced Archaerhodopsin Fluorescent Protein Voltage Indicators.Semantic proximity Read ↗

New Molecular Scaffolds for Fluorescent Voltage IndicatorsSemantic proximity Read ↗

Pado, a fluorescent protein with proton channel activity can optically monitor membrane potential, intracellular pH, and map gap junctions.Semantic proximity Read ↗

Design and characterization of a DNA-encoded, voltage-sensitive fluorescent protein.Semantic proximity Read ↗

From Plankton to Primates: How VSP Sequence Diversity Shapes Voltage SensingSemantic proximity Read ↗

Synaptic and Somatic Targeting of ArcLight, a Genetically Encoded Voltage IndicatorSemantic proximity Read ↗

Functional imaging-guided cell selection for evolving genetically encoded fluorescent indicators.Semantic proximity Read ↗

Tagging active neurons by soma-targeted Cal-LightSemantic proximity Read ↗

Genetically Encoded Glutamate Indicators with Altered Color and Topology.Semantic proximity Read ↗

Optical spike detection and connectivity analysis with a far-red voltage-sensitive fluorophore reveals changes to network connectivity in development and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.