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Article

Excitation wavelength optimization improves photostability of ASAP-family GEVIs.

Molecular brain - 4 Jun 2018

Xu Fang, Shi Dong-Qing, Lau Pak-Ming, Lin Michael Z, Bi Guo-Qiang

Abstract excerpt

Recent interest in high-throughput recording of neuronal activity has motivated rapid improvements in genetically encoded calcium or voltage indicators (GECIs or GEVIs) for all-optical electrophysiology. Among these probes, the ASAPs, a series of voltage indicators based on a variant of circularly permuted green fluorescent protein (cpGFP) and a conjugated voltage sensitive domain (VSD), are capable of detecting...

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PMID: 29866136
DOI: 10.1186/s13041-018-0374-7
PMCID: PMC5987426

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