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Article

Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP.

Nature chemical biology - 1 May 2010

Kohout Susy C, Bell Sarah C, Liu Lijun, Xu Qiang, Minor Daniel L, Isacoff Ehud Y

Abstract excerpt

In the voltage-sensing phosphatase Ci-VSP, a voltage-sensing domain (VSD) controls a lipid phosphatase domain (PD). The mechanism by which the domains are allosterically coupled is not well understood. Using an in vivo assay, we found that the interdomain linker that connects the VSD to the PD is essential for coupling the full-length protein. Biochemical assays showed that the linker is also needed for activity...

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Identifiers

PMID: 20364128
DOI: 10.1038/nchembio.349
PMCID: PMC2857593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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