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Article

Coupling sensor to enzyme in the voltage sensing phosphatase.

Nature communications - 30 Jul 2024

Yu Yawei, Zhang Lin, Li Baobin, Fu Zhu, Brohawn Stephen G, Isacoff Ehud Y

Abstract excerpt

Voltage-sensing phosphatases (VSPs) dephosphorylate phosphoinositide (PIP) signaling lipids in response to membrane depolarization. VSPs possess an S4-containing voltage sensor domain (VSD), resembling that of voltage-gated cation channels, and a lipid phosphatase domain (PD). The mechanism by which voltage turns on enzyme activity is unclear. Structural analysis and modeling suggest several sites of VSD-PD...

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Identifiers

PMID: 39080263
DOI: 10.1038/s41467-024-50319-8
PMCID: PMC11289409

Genes

PIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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