Article
A glutamate switch controls voltage-sensitive phosphatase function.
Nature structural & molecular biology - 6 May 2012
Liu Lijun, Kohout Susy C, Xu Qiang, Müller Simone, Kimberlin Christopher R, Isacoff Ehud Y, Minor Daniel L
Abstract excerpt
The Ciona intestinalis voltage-sensing phosphatase (Ci-VSP) couples a voltage-sensing domain (VSD) to a lipid phosphatase that is similar to the tumor suppressor PTEN. How the VSD controls enzyme function has been unclear. Here, we present high-resolution crystal structures of the Ci-VSP enzymatic domain that reveal conformational changes in a crucial loop, termed the 'gating loop', that controls access to the...
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