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Article

Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase.

The Journal of general physiology - 1 Jul 2024

Rayaprolu Vamseedhar, Miettinen Heini M, Baker William D, Young Victoria C, Fisher Matthew, Mueller Gwendolyn, Rankin William O, Kelley John T, Ratzan William J, Leong Lee Min, Davisson Joshua A, Baker Bradley J, Kohout Susy C

Abstract excerpt

The voltage-sensing domain (VSD) is a four-helix modular protein domain that converts electrical signals into conformational changes, leading to open pores and active enzymes. In most voltage-sensing proteins, the VSDs do not interact with one another, and the S1-S3 helices are considered mainly scaffolding, except in the voltage-sensing phosphatase (VSP) and the proton channel (Hv). To investigate its...

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Identifiers

PMID: 38771271
DOI: 10.1085/jgp.202313467
PMCID: PMC11109755

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