Article
Allele-specific transcriptional activity at type 2 diabetes-associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus.
Diabetes - 1 May 2013
Fogarty Marie P, Panhuis Tami M, Vadlamudi Swarooparani, Buchkovich Martin L, Mohlke Karen L
Abstract excerpt
Translation of noncoding common variant association signals into meaningful molecular and biological mechanisms explaining disease susceptibility remains challenging. For the type 2 diabetes association signal in JAZF1 intron 1, we hypothesized that the underlying risk variants have cis-regulatory effects in islets or other type 2 diabetes-relevant cell types. We used maps of experimentally predicted open...
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