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Using a modular massively parallel reporter assay to discover context-dependent regulatory activity in type 2 diabetes-linked noncoding regions

2023-10-10

Abstract excerpt

Most genome-wide association signals for complex disease reside in the noncoding genome, where defining function is nontrivial. MPRAs (massively parallel reporter assays) offer a scalable means to identify functional regulatory elements, but are typically conducted without regard to cell type, pairing cloned fragments with a generic housekeeping promoter. To explore the context-sensitivity of MPRAs, we screened en...

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Literature Corpus work
868e22bd-b654-58ad-a011-673486f1b67b
DOI
10.1101/2023.10.08.561391
Open publication

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Using a modular massively parallel reporter assay to discover context-dependent regulatory activity in type 2 diabetes-linked noncoding regionsDOI 10.1101/2023.10.08.561391
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