Article

Alternative <i>REST</i> Splicing Underappreciated

2017-03-22

Abstract excerpt

As a major orchestrator of the cellular epigenome, the repressor element-1 silencing transcription factor (REST) can either repress or activate thousands of genes depending on cellular context, suggesting a highly context-dependent REST function tuned by environmental cues. While REST shows cell-type non-selective active transcription 1 , an N-terminal REST4 isoform caused by alternative splicing – inclusion of...

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Literature Corpus work: 5cfa0191-362a-5a93-ae76-45714479ea84
DOI: 10.1101/119552

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